Brain glucose sensing, counterregulation, and energy homeostasis.
نویسندگان
چکیده
Neuronal circuits in the central nervous system play a critical role in orchestrating the control of glucose and energy homeostasis. Glucose, beside being a nutrient, is also a signal detected by several glucose-sensing units that are located at different anatomical sites and converge to the hypothalamus to cooperate with leptin and insulin in controlling the melanocortin pathway.
منابع مشابه
, Michel Dallaporta and Bernard Thorens Homeostasis Brain Glucose Sensing , Counterregulation , and Energy
Physiol. Soc.. ESSN: 1548-9221. Visit our website at http://www.the-aps.org/. Sci./Am. American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. © 2007 Int. Union Physiol. the physiological developments. It is published bimonthly in February, April, June, August, October, and December by (formerly published as News in Physiological Science) publishes brief review articles on ...
متن کاملBrain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation
GLUT4 in muscle and adipose tissue is important in maintaining glucose homeostasis. However, the role of insulin-responsive GLUT4 in the central nervous system has not been well characterized. To assess its importance, a selective knockout of brain GLUT4 (BG4KO) was generated by crossing Nestin-Cre mice with GLUT4-floxed mice. BG4KO mice had a 99% reduction in GLUT4 protein expression throughou...
متن کاملGlucose-sensing neurons: are they physiologically relevant?
Glucose homeostasis is of paramount concern to the brain since glucose is its primary fuel. Thus, the brain has evolved mechanisms to sense and respond to changes in glucose levels. The efferent aspects of the central nervous system response to hypoglycemia are relatively well understood. In addition, it is accepted that the brain regulates food intake and energy balance. Obesity and diabetes b...
متن کاملAmerican Diabetes Association Research Symposium: Diabetes and the Brain
From 28–30 October 2011, more than 100 people assembled in Alexandria, Virginia, to participate in an American Diabetes Association–sponsored research symposium entitled “Diabetes and the Brain.” The objective of the symposium was to discuss the role of the brain in normal and abnormal metabolism and to consider the impact of diabetes on cerebral structure and function. Symposium participants w...
متن کاملGlucose Sensing Neurons in the Ventromedial Hypothalamus
Neurons whose activity is regulated by glucose are found in a number of brain regions. Glucose-excited (GE) neurons increase while glucose-inhibited (GI) neurons decrease their action potential frequency as interstitial brain glucose levels increase. We hypothesize that these neurons evolved to sense and respond to severe energy deficit (e.g., fasting) that threatens the brains glucose supply. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Physiology
دوره 22 شماره
صفحات -
تاریخ انتشار 2007